Sunday, March 31, 2013

Eiffel Tower evacuated after bomb threat

PARIS (AP) ? Police say the Eiffel Tower has been evacuated after an anonymous caller phoned in a bomb threat.

A Paris police official says nearly 1,400 people have been evacuated following a request from tower operators after the warning Saturday. Police then searched the monument with sniffer dogs for possible explosives, and set up a broad security perimeter.

French authorities have stepped up counterterrorism measures in recent weeks amid heightened concern about threats to France over its military campaign against al-Qaida-linked fighters in Mali which began more than two months ago.

The tower is occasionally evacuated because of such warnings ? at least once last year and twice in 2011. The 324-meter (1,063-foot) tower is one of the world's top tourist attractions, with millions of visitors a year.

Source: http://news.yahoo.com/eiffel-tower-evacuated-bomb-threat-204807606.html

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Hard-Boiled Tips For Easter Eggs, Passover Food Safety - CBS Detroit

DETROIT (WWJ) ? If you?re planning an Easter egg hunt or cooking eggs for your Passover Seder, USDA has important advice to help you keep your family safe from foodborne illness throughout the Spring celebrations.

Susan Conley, director of Food Safety Education for USDA?s Food Safety and Inspection Service, said hard-boiled eggs for Easter and Passover celebrations should be prepared with care.

If you plan to eat the Easter eggs you decorate, be sure to use only food grade dye. Some people even?make two sets of eggs ? one for decorating and hiding, another for eating ? while others use plastic eggs for hiding.

For an Easter egg hunt, avoid cracking the egg shells. If the shells crack, bacteria could enter and contaminate the egg inside. Also, try to?hide eggs in places that are protected from dirt, pets and other bacteria sources. Conley said it?s especially important to keep hard-boiled eggs chilled in the refrigerator until just before the hunt.

The total time for hiding and hunting eggs should be no more than two hours. Then be sure to refrigerate the ?found? eggs right away until you eat them. Eggs found hours later or the next day should be thrown out, not eaten.

Eggs also play and important role on the Seder plate during Passover celebrations. If that egg sits out at room temperature for more than two hours, it should not be eaten. Since the hard-boiled eggs that are usually served to each person as part of the special dinner are meant to be eaten, keep those eggs in the refrigerator until ready to serve.

When shell eggs are hard-boiled, the protective coating is washed away, leaving open pores in the shell where harmful bacteria could enter. Be sure to refrigerate eggs within two hours of cooking and use them within a week. Check your refrigerator temperature with an appliance thermometer and adjust the refrigerator temperature to 40?F?or below.

For egg safety, to stay healthy and avoid foodborne illness, USDA advises:

  • Always buy eggs from a refrigerated case. Choose eggs with clean, uncracked shells
  • Buy eggs before the ?Sell-By? or ?EXP? (expiration) date on the carton
  • Take eggs straight home from the grocery store and refrigerate them right away. Check to be sure your refrigerator is set at 40?F or below. Don?t take eggs out of the carton to put them in the refrigerator ? the carton protects them. Keep the eggs in the coldest part of the refrigerator ? not on the door.
  • Raw shell eggs in the carton can stay in your refrigerator for three to five weeks from the purchase date. Although the ?Sell-By? date might pass during that time, the eggs are still safe to use.
  • Always wash your hands with warm water and soap before and after handling raw eggs. To avoid cross-contamination, you should also wash forks, knives, spoons and all counters and other surfaces that touch the eggs with hot water and soap.
  • Don?t keep raw or cooked eggs out of the refrigerator more than two hours.
  • Egg dishes such as deviled eggs or egg salad should be used within 3 to 4 days.

Source: http://detroit.cbslocal.com/2013/03/30/hard-boiled-tips-for-easter-eggs-passover-food-safety/

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True Color of Dinosaur Feathers Debated

The discovery of microscopic color-making structures in fossilized feathers has recently made it possible for scientists to picture dinosaurs and ancient birds in their natural hues.

But a group of researchers warns we might not be able to paint a Microraptor shimmery black or give the giant ancient penguin a maroon and gray coat just yet.

To reconstruct the elusive color of feathered dinosaurs, scientists have zeroed in on melanosomes, melanin-loaded organelles typically present in the cells of the skin, hair and feathers whose colors (which range from black to brown to reddish) are each associated with a specific geometry. Though the visible color of melanosomes often degrades over time, their preserved size, shape and arrangement can give some hints about their original color.

But the melanosomes encased in feather fossils today could have a distorted shape that leads scientists to the wrong conclusion about their true color, according to the new study.

Since scientists don't have hundreds of millions of years to watch how feather fossilization takes place from start to finish, Maria McNamara, of the University of Bristol, and her colleagues simulated a long burial by popping bird feathers into an autoclave, subjecting them to temperatures up to 482 degrees Fahrenheit (250 degrees Celsius) and intense pressure, about 250 times that of the atmosphere. The researchers found that the melanosomes shrank under these harsh conditions. [In Photos: Reconstructing Microraptor's Black Feathers]

Some scientists who have studied the color of fossilized feathers say they took this shrinkage into consideration and don't believe revisions are in order.

Ryan Carney, a researcher at Brown University, worked on a study of the feathers of Archaeopteryx, a species once considered to be the earliest bird that lived about 150 million years ago in what is now Bavaria in Germany. Carney and his colleagues, who published their findings last year, concluded that Archaeopteryx had a black plumage based on an electron microscope-view of hundreds of melanosomes found within a fossil.

Carney told LiveScience that although the melanosomes shrink over time, their original shape leaves an imprint in the rock.

"In the Archaeopteryx feather for example, we found that length and width of melanosomes were significantly smaller compared to those of imprints, and the shrinkage was actually quite similar to that of the McNamara et al. experiment," Carney wrote in an email.

Another researcher, Jakob Vinther, of the University of Bristol, who worked on the Archaeopteryx study ? as well as feather-color reconstructions for the giant penguin Inkayacu paracasensis and the Microraptor ? echoed Carney's remarks in comments to the journal Nature.

Even so, McNamara said another important finding of her study was that melanosomes survive fossilization even after the disappearance other non-melanin color traces, such as carotenoids, which can create brilliant shades of orange. Yellow, red, green and blue feathers all turned black during the experiments because their non-melanin pigments were destroyed and only the melanosomes survived, McNamara told LiveScience. So finding melanosomes might not necessarily mean the feathers were originally black, brown, or reddish, she added.

"The bottom line is that until we understand how the fossilisation process affects these colour-producing chemicals and structures, and until we know how to look for evidence of these in fossils, there's really no point in attempting to reconstruct colour of feathers based on melanosomes alone," McNamara wrote in an email.

The goal of figuring out the true color of dinosaur feathers goes beyond achieving better paleo-art; colors could offer a rare glimpse into the behavior of long-gone creatures.

As modern animals use their plumage in mating signals, warning signs and camouflage, body color "could yield unique insights into how ancient animals communicated with each other, and how the communication strategies used by modern animals have evolved," McNamara said.

Carney added that color could even give clues about the development of dinosaur flight.

"For example, the melanin in the Archaeopteryx wing feather would not only have provided black coloration, but also increased structural integrity that would have been advantageous during this early evolutionary stage of dinosaur flight," he wrote.

McNamara's results were published March 27 in the journal Biology Letters.

Follow Megan Gannon on Twitter and Google+. Follow us @livescience, Facebook & Google+. Original article on LiveScience.com.

Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/true-color-dinosaur-feathers-debated-182622868.html

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2 in China first known deaths from H7N9 bird flu

BEIJING (AP) ? Two Shanghai men have died from a lesser-known type of bird flu in the first known human deaths from the strain, and Chinese authorities said Sunday that it wasn't clear how they were infected, but that there was no evidence of human-to-human transmission.

A third person, a woman in the nearby province of Anhui, also contracted the H7N9 strain of bird flu and was in critical condition, China's National Health and Family Planning Commission said in a report on its website.

There was no sign that any of the three, who were infected over the past two months, had contracted the disease from each other, and no sign of infection in the 88 people who had closest contact with them, the medical agency said.

H7N9 bird flu is considered a low pathogenic strain that cannot easily be contracted by humans. The overwhelming majority of human deaths from bird flu have been caused by the more virulent H5N1, which decimated poultry stocks across Asia in 2003.

The World Health Organization is "closely monitoring the situation" in China, regional agency spokesman Timothy O'Leary said in Manila.

"There is apparently no evidence of human-to-human transmission, and transmission of the virus appears to be inefficient, therefore the risk to public health would appear to be low," O'Leary said.

One of the two men from Shanghai, who was 87, became ill on Feb. 19 and died on Feb 27. The other man, 27, became ill on Feb. 27 and died on March 4, the Chinese health commission said. A 35-year-old woman in the Anhui city of Chuzhou became ill on March 9 and is being treated.

The Chinese Center for Disease Control and Prevention conducted tests and confirmed Saturday that all three cases were H7N9, the health commission said.

Scientists have been closely monitoring the H5N1 strain of the virus, fearing that it could mutate into a form that spreads easily among people, potentially sparking a pandemic. So far, most human cases have been connected to contact with infected birds.

Source: http://news.yahoo.com/2-china-first-known-deaths-h7n9-bird-flu-092118642.html

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The next $1B markets in tech - Business Insider

Reuters

Social e-commerce is going to be BIG.

New tech industries start small but can grow into permanent, billion dollar slices of infrastructure. Sometimes that seems to happen overnight ? like with smartphones.

And sometimes it takes years ? like with the dumb phones that grew like mold from the mid-1990s through the late 2000s.

And now, for example, the prevalence of smart mobile devices has spurred the mobile app industry, an entirely new piece of infrastructure which supports thousands of companies and billions of dollars in sales.

There is a discussion going on over at Quora about which industries are poised to gain the next $1 billion.

We pulled out a few of the most interesting and explored why they're set to explode.

Source: http://www.businessinsider.com/the-next-1b-markets-in-tech-2013-3

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Eiffel Tower evacuated after bomb threat

(AP) ? The Eiffel Tower was evacuated Saturday night after an anonymous caller phoned in a bomb threat, police said.

Nearly 1,400 people were sent away from the tourist attraction following a request from tower operators after the warning, a Paris police official said. Police then searched the monument with sniffer dogs, and set up a security perimeter.

No explosives were found and the site was to be reopened, the official said on condition of anonymity because she wasn't authorized to speak publicly.

French authorities have stepped up counterterrorism measures in recent weeks amid heightened concern about threats to France over its military campaign against al-Qaida-linked fighters in Mali which began more than two months ago.

The tower is occasionally evacuated because of such warnings ? at least once last year and twice in 2011. The 324-meter (1,063-foot) tower is one of the world's top tourist attractions, with millions of visitors a year.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-03-30-EU-France-Eiffel-Tower/id-674c32517d874b2097a462bd6cd64f2e

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Apple's 'Maps Ground Truth Specialists' fix Map app flubs

Apple's Maps mess of six months ago is a distant memory for some, but not for the Cupertino company, which has worked quickly to rectify matters and improve its map app, introduced as part of its iOS 6 mobile operating system. That damage control includes hiring employees with the title of "Maps Ground Truth Specialists" around the globe to make sure Apple's maps are up to snuff.

While Apple isn't the first company to have the Orwellian-sounding position of "Maps Ground Truth Specialists" ? Google has them, too ? it's noteworthy because of Apple's map flubs, something that caused CEO Tim Cook to make a public apology.

In the United States, those flubs included initially showing the Brooklyn Bridge as almost plunging into the water and marking a Florida supermarket site as one for a hospital.

Right now, there are seven openings for "Maps Ground Truth Specialists" around the world, including one in the United States. That role, Apple says in the job description, will include:

  • Testing new releases of map code and data around the U.S.
  • Collecting ground truth data to allow for analysis of the impact of potential map code or data changes relative to known truth.
  • Utilizing local expertise to provide feedback about U.S.-specific mapping details.
  • Evaluating competing products in-region relative to our maps.

As you can see, there are jobs all over the globe, including Australia. There last fall, police were warning drivers not to use Apple Maps because it wrongly placed the city of Midura in a national park, leaving some motorists stranded and in a snake-infested area.

? Via The Verge

Check out Technology, GadgetBox, DigitalLife and InGame on Facebook, and on Twitter, follow Suzanne Choney.

Source: http://feeds.nbcnews.com/c/35002/f/653377/s/2a2439b3/l/0L0Snbcnews0N0Ctechnology0Ctechnolog0Capples0Emaps0Eground0Etruth0Especialists0Efix0Emap0Eapp0Eflubs0E1C9142594/story01.htm

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Afghans warned: the taxman is coming after you

By Katharine Houreld

KABUL (Reuters) - One of Afghanistan's most surprising success stories lies tucked away on a potholed street notorious for suicide bombings and lined with rusting construction equipment.

The work of the country's top tax collector is more inspiring than the view from his office in Kabul. Taxes and customs raised $1.64 billion last financial year, a 14-fold increase on 10 years ago. That means, now, the government can pay just over half of its recurrent costs such as salaries.

Thanks to tougher enforcement procedures, Afghanistan's tax to GDP ratio today stands above 11 percent - ahead of neighboring Pakistan's dismal 9 percent.

Increasing revenues is vital as donors begin reducing aid ahead of the 2014 drawdown of NATO troops, who have provided the backbone for security since U.S. forces invaded after the September 11 attacks on the United States.

By the end of this year the United States alone will have spent $100 billion on Afghan reconstruction. But future pledges are a fraction of that.

"We are largely dependent on international aid. We would like to be independent," said Abdurrahman Mujahid, the new head of the revenue department. "I would like a sustainable Afghanistan for all the children."

Despite rising revenues, the government will rely heavily on donors for years to come. Taxes, customs and mining revenue will only meet $2.5 billion out of a $7 billion budget this year.

Most of the revenue comes from large corporate taxpayers, who complain their payments have not improved power cuts, potholed roads or security.

Corporations pay a flat tax of 20 percent - the same rate for an individual earning over $2,000 a month.

But unlike developed countries where personal income tax generates a sizeable chunk of revenue, most Afghans scoff at the idea of giving the government some of their meager earnings.

The average annual income, in a country ranked one of the world's poorest, is just $470, according to the World Bank. Those making less than $100 a month don't have to pay tax.

"It's not a good government," said moneychanger Abdurrahman Arif, 28, as he held a wad of soiled notes and scanned for customers. "I don't pay tax. The rich people don't and the government should go to them before they come to me."

Afghanistan has a similar problem to neighboring Pakistan - the very wealthy don't pay their share, and weak institutions often have little way of forcing them.

Authorities admit that taxing the rich isn't easy in a country where the powerful often command militias. But Mujahid promises tax evaders will "be introduced to the law enforcement agencies".

SUBSTANTIAL ACHIEVEMENT

Much of Afghanistan's money is in an undocumented black economy. Corruption is endemic and the country produces 90 percent of the world's opium. Billions of dollars in cash leave the country every year in suitcases.

The security situation is discouraging. Taliban and other militias have made gains in many areas as foreign combat forces wind down their missions.

But some Afghans still manage to make money. Many businesses are fuelled by the aid dollars that have poured into the country over the last decade. Luxury supermarkets, travel agencies and stationery shops crowd the capital's streets.

A U.S. embassy official in Kabul commended Afghanistan's ability to raise tax revenues.

"It's a pretty substantial achievement," the official said, but noted the nation still faced a large funding gap, partly because of its huge security bill.

"It's going to continue being a problem until they can get revenues from the extractive industry, and that's going to take some time," the official said, referring to Afghanistan's rich but undeveloped mineral deposits.

Donors currently pay for just under half Afghanistan's operating costs - mostly government salaries - and more than three-quarters of all development projects like roads, dams and electricity equipment.

Rampant corruption means this money is often stolen, angering donors, fuelling anti-government rage and keeping aid from some of the world's neediest families.

Donors hope that if Afghans foot more of the bill for public services they may become less tolerant of graft from their leaders.

PUGNACIOUS PREDECESSOR

Mujahid, the new head of the revenue department, has large shoes to fill. His predecessor Ahmad Shah Zamanzai oversaw much of the department's growth and didn't shrink from confrontation.

When a vice-president refused to pay tax on income from renting out houses he owned, Zamanzai threatened to leak it to the press. Elections were approaching. The vice president paid up.

Under Zamanzai, the tax department jailed more than 20 tax evaders, froze bank accounts, slapped on travel bans and shuttered the premises of businesses that refused to pay.

In one showdown, he took on the glitzy wedding halls that have mushroomed up in the capital. When the 60 or so venues refused to pay their dues, he had police padlock a dozen of the biggest until the rest fell into line.

Zamanzai was appointed head of the state-run Pashtany Bank as part of a bureaucratic reshuffle this month. His first task, he said, would be to use skills honed in the tax department to extract overdue loan repayments from powerful Afghans.

But the tough tax enforcement has angered some businessmen.

Najib Ullah Latify's spotless factory, full of humming machinery and rows of workers in blue overalls and yellow hard hats, stands a few minutes drive from the tax office. High Standard Pipe employs 850 people and supplies pipes for projects providing clean water all over Afghanistan.

Latify said he'd expand but harassment from the tax man was hurting his business.

In recent years, he says, he's been repeatedly overcharged by the tax office and promised refunds have not been credited. Officials frequently offer to slash his tax bill in return for bribes, he added. When he refuses, he says, officials disrupt his imports and suspend his license.

"I don't know what to do, I have shouted everywhere that they are ruining my business," he said.

"I don't mind paying taxes. Even if 60 percent of it is spent on drinking and shopping and trips for (politicians') wives, maybe 40 percent will go to schools or hospitals. But they must tax me correctly."

The new tax chief, Mujahid, was not familiar with Vitaly's case, but promised to investigate. More than 10 tax collectors - whose basic salaries start at $180 a month - have been fired for corruption in the last two years.

"Corruption is a part of public life in Afghanistan," said Mujahid. "We have the aim to make this department corruption-free."

This year he's planning to finish computerizing tax records, usher through a law on Value Added Tax, and strengthen collection in the provinces - more than 90 percent of government taxes currently come from the capital.

"There's a lot of achievements, but for sure we have problems, and the biggest problem is corruption," he said.

(Editing by Jeremy Laurence)

Source: http://news.yahoo.com/afghans-warned-taxman-coming-075922090.html

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Sicily revokes permission for military satellite station

PALERMO, Italy | Fri Mar 29, 2013 3:57pm EDT

PALERMO, Italy (Reuters) - The Sicilian regional government in Italy has revoked permission for the United States to build a military satellite station on the island, its governor said on Friday, after protests by residents who said it could pose a health risk.

The planned ground station is part of the Mobile User Objective System (MUOS), an ultra high-frequency satellite network aimed at significantly boosting communications capacity for the U.S. military and its allies.

Concerns about the effect the station's electromagnetic waves could have on the health of residents around the town of Niscemi, including fears that the waves could cause cancer, have provoked protests on the island.

A U.S. military official said the United States hoped to allay any health concerns and would try to reach an agreement with the Italian government to get permission to build the facility.

The regional government of the semi-autonomous island last month delayed construction and called for an independent study into its health and environmental impact.

The Italian government said this month the demonstrations risked compromising operations at Sigonella, a U.S. naval base in Sicily.

"Through the relevant department, permission for the construction of MUOS has been definitively withdrawn," Sicilian Governor Rosario Crocetta told reporters in the island's capital of Palermo on Friday.

He did not say whether the decision to revoke permission for the site was related to the study or to health concerns.

Crocetta's remarks came a day before a planned protest expected to draw several thousand in Niscemi, which local groups of the governor's own Democratic Party were due to attend.

Lieutenant Colonel Monica Matoush, a spokeswoman for the U.S. Defense Department, said the U.S. military was confident that studies of the satellite system would show it was safe.

"We are committed to working with Italian health authorities to address health concerns raised by the local population," she said in emailed comments to Reuters.

The satellite network also has stations in the United States and Australia.

In a visit to Italy in January, then-U.S. Defense Secretary Leon Panetta said he understood the concerns of residents but that U.S. studies had concluded there would be no health risk.

(Reporting by Vladimiro Pantaleone and Naomi O'Leary; Editing by Pravin Char)

Source: http://feeds.reuters.com/~r/reuters/scienceNews/~3/CYaUYWR1b48/story01.htm

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Three dozen indicted in Atlanta cheating scandal

ATLANTA (AP) ? Juwanna Guffie was sitting in her fifth-grade classroom taking a standardized test when, authorities say, the teacher came around offering information and asking the students to rewrite their answers. Juwanna rejected the help.

"I don't want your answers, I want to take my own test," Juwanna told her teacher, according to Fulton County District Attorney Paul Howard.

On Friday, Juwanna ? now 14 ? watched as Fulton County prosecutors announced that a grand jury had indicted the Atlanta Public Schools' ex-superintendent and nearly three dozen other former administrators, teachers, principals and other educators of charges arising from a standardized test cheating scandal that rocked the system.

Former Superintendent Beverly Hall faces charges including conspiracy, making false statements and theft because prosecutors said some of the bonuses she received were tied to falsified scores. Hall retired just days before the findings of a state probe were released in mid-2011. A nationally known educator who was named Superintendent of the Year in 2009, Hall has long denied knowing about the cheating or ordering it.

During a news conference Friday, Howard highlighted the case of Juwanna and another student, saying they demonstrated "the plight of many children" in the Atlanta school system.

Their stories were among many that investigators heard in hundreds of interviews with school administrators, staff, parents and students during a 21-month-long investigation.

According to Howard, Juwanna said that when she declined her teacher's offer, the teacher responded that she was just trying to help her students. Her class ended up getting some of the highest scores in the school and won a trophy for their work. Juwanna felt guilty but didn't tell anyone about her class' cheating because she was afraid of retaliation and feared her teacher would lose her job.

She eventually told her sister and later told the district attorney's investigators. Still confident in her ability to take a test on her own, Juwanna got the highest reading score on a standardized test this year.

The other student cited by Howard was a third-grader who failed a benchmark exam and received the worst score in her reading class in 2006. The girl was held back, yet when she took a separate assessment test not long afterward, she passed with flying colors.

Howard said the girl's mother, Justina Collins, knew something was wrong, but was told by school officials that the child simply was a good test-taker. The girl is now in ninth grade, reading at a fifth-grade level.

"I have a 15-year-old now who is behind in achieving her goal of becoming what she wants to be when she graduates. It's been hard trying to help her catch up," Collins said at the news conference.

The allegations date back to 2005. In addition to Hall, 34 other former school system employees were indicted. Four were high-level administrators, six were principals, two were assistant principals, six were testing coordinators and 14 were teachers. A school improvement specialist and a school secretary were also indicted.

Howard didn't directly answer a question about whether prosecutors believe Hall led the conspiracy.

"What we're saying is, is that without her, this conspiracy could not have taken place, particularly in the degree that it took place. Because as we know, this took place in 58 of the Atlanta Public Schools. And it would not have taken place if her actions had not made that possible," the prosecutor said.

Richard Deane, an attorney for Hall, told The New York Times that Hall continues to deny the charges and expects to be vindicated. Deane said the defense was making arrangements for bond.

"We note that as far as has been disclosed, despite the thousands of interviews that were reportedly done by the governor's investigators and others, not a single person reported that Dr. Hall participated in or directed them to cheat on the C.R.C.T.," he said later in a statement provided to the Times.

The tests were the key measure the state used to determine whether it met the federal No Child Left Behind law. Schools with good test scores get extra federal dollars to spend in the classroom or on teacher bonuses.

It wasn't immediately clear how much bonus money Hall received. Howard did not say and the amount wasn't mentioned in the indictment.

"Those results were caused by cheating. ... And the money that she received, we are alleging that money was ill-gotten," Howard said.

A 2011 state investigation found cheating by nearly 180 educators in 44 Atlanta schools. Educators gave answers to students or changed answers on tests after they were turned in, investigators said. Teachers who tried to report it faced retaliation, creating a culture of "fear and intimidation," the investigation found.

State schools Superintendent John Barge said last year he believed the state's new accountability system would remove the pressure to cheat on standardized tests because it won't be the sole way the state determines student growth. The pressure was part of what some educators in the system blamed for their cheating.

A former top official in the New York City school system who later headed the Newark, N.J. system for three years, Hall served as Atlanta's superintendent for more than a decade, which is rare for an urban schools chief. She was named Superintendent of the Year by the American Association of School Administrators in 2009 and credited with raising student test scores and graduation rates, particularly among the district's poor and minority students. But the award quickly lost its luster as her district became mired in the scandal.

In a video message to schools staff before she retired in the summer of 2011, Hall warned that the state investigation launched by former Gov. Sonny Perdue would likely reveal "alarming" behavior.

"It's become increasingly clear that a segment of our staff chose to violate the trust that was placed in them," Hall said. "There is simply no excuse for unethical behavior and no room in this district for unethical conduct. I am confident that aggressive, swift action will be taken against anyone who believed so little in our students and in our system of support that they turned to dishonesty as the only option."

The cheating came to light after The Atlanta Journal-Constitution reported that some scores were statistically improbable.

Most of the 178 educators named in the special investigators' report in 2011 resigned, retired, did not have their contracts renewed or appealed their dismissals and lost. Twenty-one educators have been reinstated and three await hearings to appeal their dismissals, said Atlanta Public Schools spokesman Stephen Alford.

APS Superintendent Erroll Davis said the district, which has about 50,000 students, is now focused on nurturing an ethical environment, providing quality education and supporting the employees who were not implicated.

"I know that our children will succeed when the adults around them work hard, work together, and do so with integrity," he said in a statement.

The Georgia Professional Standards Commission is responsible for licensing teachers and has been going through the complaints against teachers, said commission executive secretary Kelly Henson. Of the 159 cases the commission has reviewed, 44 resulted in license revocations, 100 got two-year suspensions and nine were suspended for less than two years, Henson said. No action was taken against six of the educators.

Source: http://news.yahoo.com/3-dozen-indicted-atlanta-cheating-scandal-214241949.html

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Kickstarted Video Game Console Gets Ready for Debut - Hit & Run ...

The next Super Nintendo or the next Atari Jaguar?Source: OuyaA new video game console is about to hit the stores, and it?s not produced by Sony, Microsoft or Nintendo, the current gorillas dominating the market.

Ouya, a much more modest $99 console, running off Android?s operating system, will be hitting the market in June and will be available in stores like Target and Best Buy.

The launch of Ouya will mark the culmination of an interesting experiment. The completion of the console?s development and release was paid for via a Kickstarter campaign that drew in $8.5 million in donations. Kickstarter campaigns have been successful in helping fund products and artistic ventures. But as gamers know, the days of a console being just a product are long over. Game consoles also now provide persistent services. Games can be purchased and downloaded via console these days, as can rentals of movies and television shows. ?

Ouya?s challenge will be not just getting the console into gamers? hands, but in being able to continue to operate an online market given its economically modest origins. I wrote about Ouya back in August and the skepticism over whether such a business model could possibly succeed.

Chris Kohler at Wired got his hands on the console in San Francisco just recently. It obviously is not going to be competing with the Xbox or the Playstation for the high-end games, but that?s absolutely not the point of the system. Rather, it intends to be an avenue for smaller-game developers to more easily find an audience. Because of the huge boom of indie game development, the success of the system will depend on the ability for creators to use their marketplace and the ease of consumers in connecting to the types of games they?d like. Kohler notes the system Ouya will be using for its marketplace incorporates both an algorithm and human curation:

It?s common knowledge in the world of iOS apps that you get noticed in one of two ways: Get featured in the store via Apple?s secretive process of internal curation, or (by hook or by crook) get onto the top-grossing or most-downloaded charts.

?We don?t think downloads or revenue are good indicators of what a good game is,? [Ouya CEO Julie] Uhrman says. To that end, Ouya is crafting its own automatic algorithm that will determine whether or not a game is any good, based on other players? behaviors. How many times have they played it? For how long are they playing it? When a player turns on their Ouya, is it the first game they immediately boot up? All of these factors will influence how prominently games are positioned in the Ouya marketplace when a player clicks on ?Discover.?

There will also be an element of hand-picked curation on Ouya. That process, Uhrman says, will be led by Kellee Santiago, co-founder Journey creator thatgamecompany and now Ouya?s head of developer relations. All new games will go into an area called the ?Sandbox,? and will be pulled up into the ?Recommended? feed after they hit the jackpot on the automated fun algorithm, or are selected by Santiago?s team.

There?s still plenty of skepticism among gamers that Ouya?s business model can actually work (just read the comments under Kohler?s story). Portability and simplicity has contributed to the success of mobile phone gaming apps. Do people really want to play such games on their televisions? We will find out beginning in June. For the curious, PC Magazine has a slide show of some games that will be available at launch via Ouya.

Even if Ouya fails, console developers will likely learn a lot about building economic systems that accommodate the ever-changing nature of the gaming marketplace.

Source: http://reason.com/blog/2013/03/29/kickstarted-video-game-console-gets-read

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Algeria's southern unemployed demand oil jobs

In this photo dated March 14, 2013, protesters gestures during a demonstration by thousands of young unemployed men demanding jobs in the oil industry in Algeria?s southern city of Ouargla. Protests by the unemployed in southern Algeria are raising the specter of rising unrest in the country?s sensitive oil regions, and are increasingly attracting the attention of al-Qaida. (AP Photo/Nabil Zahani)

In this photo dated March 14, 2013, protesters gestures during a demonstration by thousands of young unemployed men demanding jobs in the oil industry in Algeria?s southern city of Ouargla. Protests by the unemployed in southern Algeria are raising the specter of rising unrest in the country?s sensitive oil regions, and are increasingly attracting the attention of al-Qaida. (AP Photo/Nabil Zahani)

In this photo dated March 14, 2013, a demonstrator holds a sign reading ?I am Algerian, where are my rights?? during a protest by thousands of young unemployed men in Algeria?s southern city of Ouargla. Protests by the unemployed in southern Algeria are raising the specter of rising unrest in the country?s sensitive oil regions, and are increasingly attracting the attention of al-Qaida. (AP Photo/Nabil Zahani)

(AP) ? Protests by the unemployed in southern Algeria are raising the specter of rising unrest in the country's sensitive oil regions, and are increasingly attracting the attention of al-Qaida.

Algeria's vast, sparsely populated Sahara only holds 10 percent of the country's population but it is home to this North African country's enormous oil and gas reserves ? the basis of the entire economy and the source of the government's power. Those who live there claim they aren't benefiting from that wealth, and can't get jobs with the oil companies.

Now al-Qaida has praised the protesters, raising the possibility that it is seeking support among the disaffected groups. The government is rushing to address the protesters' demands, but hasn't yet convinced them that it's serious.

Some 10,000 people ? an enormous number for the lightly populated region ?demonstrated on March 14 in Algeria's southern oil city of Ouargla, and thousands more later protested in another southern oil town, Laghouat.

"We want access to jobs in the oil companies, and not just the low-value ones like drivers and security guards; we want to be in the administration," Tahar Belabes, the head of the National Committee for Defense of the Rights of the Unemployed, which organized the demonstration, said by telephone from Ouargla.

"We just want the same employment possibilities. It's not normal that we live in the region where the oil and gas is located but don't benefit from it."

While youth unemployment is widespread in Algeria, and the rest of North Africa, the southerners say they are particularly discriminated against. There is also a widespread distrust of government officials, who are believed corrupt and skimming off the country's vast oil receipts.

Prime Minister Abdelmalek Sellal acknowledged on March 16 that the demonstrators' demands are legitimate and the government hurriedly announced a string of measures to address the perceived geographical bias in oil jobs. Oil companies will be obliged to give priority to job candidates from the south and recruitment must occur through registered employment agencies. The government announced that job-training centers would be set up to ready candidates for jobs with oil companies and hotels.

The demonstrations, however, have not stopped, and on Monday hundreds protested in the desert towns of Ghardaia and Oued Souf.

"The demonstrations are continuing because the young unemployed don't believe in official promises and they don't trust the local government representatives or their parliamentarians ? they want to negotiate directly with the government," said Kamal Zaidi, a member of an unemployed group in Laghouat and a human rights activist.

Most worrying for the government is that, on Friday, Al-Qaida's North African branch expressed solidarity with the demonstrations, slamming what they say is the corrupt use of the country's resources.

"The events of the south and the call of the people to protest in the streets is the natural response to the policy of marginalization and nepotism used by the corrupt Algerian regime," said the message posted on extremist websites.

Al-Qaida's signature tactic around the world has been to find marginalized groups in remote areas and espouse their cause, much the way they did with the disenfranchised Tuareg tribesmen in northern Mali, setting up a foothold that later became a de facto state before they were routed by the French in February.

In January, an al-Qaida-linked group for the first time attacked one of the country's remote desert gas plants.

While the leaders of Al-Qaida's Algerian branch are predominantly from the populous north, the leader of the attack on the Ain Amenas gas complex in January that left 37 hostages dead was a southerner ? Lamine Bencheneb, part of the radical Sons of Sahara armed Islamic group.

In the attack, the multinational team of militants appeared to know the complex inside and out, sparking reports that they may have had allies among the site's local drivers who had gone on strike over low pay just weeks earlier.

Geoff Porter, a veteran Algeria analyst with the North Africa Risk Consulting firm said the "unevenness" of past government investment programs have left a legacy of distrust in the south ? a region that also lacks the educational opportunities to produce the necessary skills for oil sector jobs.

Part of the problem, he added, is that the hydrocarbon industries don't require very much employment and there is little else going in these remote communities after the desert tourism industry dried up.

In attempt to curb the recent demonstrations, the government sent local parliamentarians, mostly from the ruling party, back to their towns in the south to hold meetings, but most of these were boycotted by the committees of the unemployed.

"The Algerian state has always had a policy of national investment and a great deal of money has been invested in the south, just like the other regions," said Mohammed Dhimi, one of the members of parliament from the south. "Perhaps the investments were not well thought-out or misdirected or didn't respond to the agricultural and industrial needs of the people."

"The protesters may sense that they have built up some momentum and that they are going to continue their protests until they see meaningful steps taken to deliver on the prime minister's promises," he said.

Belabes, the head of the unemployment committee, promised a new round of demonstrations in the coming days.

__

Schemm reported from Rabat, Morocco.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-03-30-Algeria-Southern%20Discomfort/id-a99447f6bb714530b4b3944b4055f1e7

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Saturday, March 30, 2013

South Africa: Experience The Safari Like Never Before

The South African safari truly is an experience that no other safari anywhere else can replace. While the wildlife of South Africa does not encompass the South African experience, the South Africa safari tours are a big part of the complete South African experience. The nearly impenetrable forests in the heartland shelter a wide variety of flora and fauna indigenous to the place. While the South Africa safari tours give the perception of safety, the fact that the animals are wild cannot be ignored. The opportunity to see the big five in their natural habitats, if not in a safari is not possible. While the rangers and guides ensure safety and controlled forays, the South Africa safari tours take tourists into the territories of the wild animals.

The South African safari gives the rare opportunity to witness the majesty of the animals in the most natural settings with little or negligible human interference. The awe-inspiring sights and sounds is exhilarating while being heart-stopping. Large herds of elephants, innumerable birds flying in formation unknown to the limited imagination of man, a pride of lions, the stark color of a zebra against the dry grass landscape, each new sight on a South Africa safari is a sight that gets seared into memory. The south african safari is an experience that people carry forward through life.
Though numerous places in South Africa offers safaris, the most authentic South Africa safari are through the Kruger National Park in Limpopo and Mpumalanga provinces. The safari through the Kruger National Park and the neighboring privately owned reserves give tourists the opportunity to spot the big five, i.e. the elephant, the rhino, the buffalo, the lion and the leopard. The high concentration of leopards in private reserves such as Sabi Sand near Kruger National Park ensures that visitors on the safari see the leopard if not all the big five.

While there are many routes to experience the safari, accommodation within the National parks and the reserves add to the South Africa safari experience. The accommodation and the safari are best booked in advance as they do tend to fill up fast. The safari experience tends to be easier the second time as the eyes adjust to looking for wildlife in the natural surroundings. Late winter and early spring might be the best time to experience the safari as the grass does not grow very high and the water reserves are limited, giving more opportunity to spot the big five. Cameras and binoculars are the best companions on safaris.

Source: http://www.articlesnatch.com/Article/South-Africa--Experience-The-Safari-Like-Never-Before/4510472

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Police: Babysitter locked toddlers in closet

By Lauren DiSanto, NBCPhiladelphia.com

A teenage babysitter from Newark, Del., is facing a dozen charges of endangering the welfare of a child after police say she locked up 3-year-old twins in the closet of her apartment.

New Castle County police say Veronica Miller, an unlicensed daycare provider, would lock the twins in a closet while she drove to another location to pick up several other children she also watched.

After getting a tip, police went to Miller's apartment on Thursday afternoon.

A maintenance worker let officers inside the apartment, where they found a chair wedged in the hallway between the closet and bathroom door. Police say when they opened the door, they saw the twin toddlers sleeping on the floor with pillows and blankets.

Police say this wasn't the first time this had happened and believe Miller had been doing this since mid-February.

The twins were in good health.

The Division of Family Services is helping police with the investigation.

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/2a25c255/l/0Lusnews0Bnbcnews0N0C0Inews0C20A130C0A30C290C175219270Epolice0Ebabysitter0Elocked0Etoddlers0Ein0Ecloset0Dlite/story01.htm

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UAE real estate rides on growing confidence, consolidation - AME Info

Tasweek predicts a sustained rebound within the next months driven by rising confidence in the Dubai market and strong market fundamentals in Abu Dhabi.

More responsive legislation and robust real estate laws are also expected to quell local fluctuations on services and returns across industry. Al Awar notes that there are some concerns that must be addressed in order to sustain organic growth, such as affordable housing and varying financing options for real estate customers.

Abu Dhabi

The past year saw a fluctuating 5 to 12% slide in Abu Dhabi rents due to the entrance of new units all over the emirate. Major initiatives such as new regulations on housing allowances for government employees, the announcement of key government-backed projects and an Dhs330bn local stimulus package are expected to accelerate demand and market growth in Abu Dhabi for 2013, though.

More industry consolidation has been observed in Abu Dhabi after the merger of major developers Aldar and Sorouh. Consolidation is expected to extend beyond companies and towards government entities and projects as well. Upcoming rollouts such as 200 villas in Al Reef Contemporary Village and a Mosque, Community Center and mini-market in the Mediterranean Village will further boost the market. Other projects slated for opening in the coming years, such as 'The District' retail destination in Saadiyat Island and the mixed-use Sowwah Central in Al Maryah Island will further strengthen Abu Dhabi's real estate claim.

Another trend to watch out for is Abu Dhabi's lead in sustainability integration in light of Masdar activities and Estidama regulations. Sustainability initiatives in 2013 are expected to be small-scale, though, as owners have not yet fully embraced 'green' leases. Overall, the Abu Dhabi property is expected to sustain its market momentum, especially with the local Government pledging Dhs6bn per year to boost economic activity.

Dubai

While residential rents in Dubai rose 7 to 10% over the past 3 months, the emirate has been able to maintain its popularity as a preferred destination offering flexible payment schemes. Experts forecast a 10 to 17% increase in rental rates across the Dubai market in 2013, driven by several new project announcements made in late 2012. The emirate's recent posting of a 34-month closing high on its stock market index bodes well for its investment outlook. Barring major construction delays, around 36,000 new apartments and villas could go online from 2013 to 2015. Amidst broad options, Dubai tenants are expected to go for localities offering quality units and amenities.

Most of the residential supply is expected in locations including Dubai Land Residences, Motor City, Dubai Sports City, and Liwan. Looking forward, major developments in the pipeline such as the Dhs6bn Blue Waters Island and an Dhs3.67bn hotel and branded serviced apartment project in Downtown Dubai and the announcement of an Dhs3.67bn investment influx by Investment Corporation of Dubai (ICD) and Brookfield Asset Management reflect the resurgence of Dubai's property market.

Nationwide, the recent announcement of planned property regulations aimed at settling down prices and eliminating market speculation has prevented what could have been a spiraling of rents in 2013. The UAE Central Bank has declared that a proposed cap on mortgage lending - for expatriates at 50% of the property's value and 70% for UAE Nationals - will be discussed during the second half of this year.

The adoption of more transparent approaches for service charges and operating costs arrangements is also highly anticipated that will significantly reduce the number of rent disputes.

Al Awar added that this year will build on the transitional nature of 2012 to make the UAE property markets more robust and sustainable. He advised all sector players and stakeholders to closely monitor market movements to take advantages of opportunities that are quickly arising in what Tasweek believes will be a watershed year for the business.

Source: http://www.ameinfo.com/uae-real-estate-rides-growing-confidence-335438

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Amazon acquires Goodreads, aims to make better recommendations for Kindle users

Amazon acquires Goodreads, aims to make better recommendations for Kindle users

So, Amazon has a reading platform called Kindle. Goodreads has a platform that makes fairly excellent suggestions when it comes to reading materials. You probably see where this is going. This evening, Amazon announced that it was acquiring one of the more popular reading recommendation engines, and while the outfit isn't making clear what it plans to do with the technology, it shouldn't take a scholar to see how it'd bolster Amazon's Kindle reader line as well as its array of Kindle apps. (What'll happen to Shelfari, however, is perhaps a bigger mystery.)

Russ Grandinetti, Amazon's vice president of Kindle Content noted that "Goodreads has helped change how we discover and discuss books and, with Kindle, Amazon has helped expand reading around the world -- together, we intend to build many new ways to delight readers and authors alike." It's entirely likely that this will add another social angle to the Kindle framework, further establishing an ecosystem where friends could see suggestions based on what they're independently reading through their own Kindle accounts. The companies are expecting the deal to be finalized in Q2, which suggests that we'll see a proper integration just as back-to-school season begins. Right, guys?

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Source: Amazon, Goodreads

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/SOhzmKmoIpU/

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5 Handy Tools to Boost Productivity in Business - Small Businesses ...


HandHarsh economic times and general demands have many businesses working in overdrive. With meetings to organize, staff to accommodate, and customers to please, there just doesn?t seem to be enough time to get it all done. It can make for a frustrating environment, but thanks to technology, there are solutions.

The internet has brought us an abundance of tools that offer the ability to keep production moving. These five tools have the potential to come in handy in both the office and home setting.

1. Remember the Milk

Remember the Milk has a lot to offer business pros and homebodies alike. This app comes with several interesting perks, including the ability to:

  • ?Share tasks
  • ?Manage tasks offline
  • ?Integrate with Google Calendar
  • ?Receive notifications via email, IM, or text

At the basic level, Remember the Milk is great at creating lists that you can easily manage in a variety of unique ways. It?s all cloud-based, so you can pretty much access it at any time, on any device.

2. Google Drive

Although DropBox has been on top of the online file storage game for a while, Google Drive has proven to be a worthy alternative. Available for web use, Android, and even iOS, the service that started out as a glorified version of Google Docs has matured into a nice little tool all its own. In addition to storage, it serves up real-time updates, the ability to download documents, and full-on editing capabilities. Google Drive is also cloud driven, so you can access your data any time on a multitude of devices.

3. Objectiveli

Objectiveli is another utility that comes in handy for task management. This web-based tool provides you with a streamlined interface that allows you to track tasks, goals, and objectives in real-time. It helps teams and organizations stay focused by providing a centralized view of everything that has been assigned, thus minimizing the need for handwritten notes, spreadsheets, and internal email communications. Objectiveli is highly recommended for team orientated businesses, and individuals who want to see what?s ahead of them in big picture form.?

4. Rapportive

What we have here is a tool that enhances the power of your Gmail account. Rapportive delivers rich data about your contacts directly to your inbox. It pulls data about these contacts from a number of different sources, including Facebok, LinkedIn, Twitter, and Quora. So if it?s someone from LinkedIn, you would be able to see updates and other activity without actually visiting the site. ?Hence the name, this tool is all about getting to better know your contacts so you can form a ?rapport?.

Rapportive is a free tool available as a browser extension for Chrome, Firefox, Mailplane, and Safari. This one can be extremely handy for marketers scouting the web for leads, or the consumer who simply wants to know more about a company before doing business with them.

5. Pomio

Sales people, managers, programmers, and people all over the world are practicing the Pomodoro Technique, the time management method developed by Francisco Cirillo many years ago. Some say its overblown hogwash. Others swear by it. Lost? This five-step overview sums it up:

  • ?Outline a specific task
  • ?Set your timer to 25 minutes
  • ?Work on the task for 25 minutes straight through?
  • ?Break briefly for about three to five minutes
  • Take a longer break of 15 to 30 minutes between each set (every four 25-minute periods)

The concept is simple enough, but getting the most from it has proven challenging. That?s where tools like Pomio come in. Pomio is an iOS app that acts as a Pomodoro timer, but it does so much more. It fully supports task management by allowing you to enter specific objectives and properly time them to make sure you are doing the method correctly. With access to detailed analytics, you can find out where you?re excelling, and where you need improvements. This is a fun little tool that can actually help you get more done if you play fair.

Conclusion
Steady productivity is one of those intangible assets with value that simply can?t be measured. But as you know, keeping it a high level is a task in and of itself. With everything from social networks to reality shows in the mix, the potential for distraction is greater than ever. On the bright side, there are plenty of good productivity tools at your disposal. All you gotta do is find the right ones and use them.

Chiko Noguchi is a best practices activist and advocate for a leading provider of event marketing services.
Image courtesy John-Morgan

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Source: http://smallbusinessesdoitbetter.com/2013/03/5-handy-tools-to-boost-productivity-in-business/

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Parkinson's disease protein gums up garbage disposal system in cells

Friday, March 29, 2013

Clumps of ?-synuclein protein in nerve cells are hallmarks of many degenerative brain diseases, most notably Parkinson's disease.

"No one has been able to determine if Lewy bodies and Lewy neurites, hallmark pathologies in Parkinson's disease can be degraded," says Virginia Lee, PhD, director of the Center for Neurodegenerative Disease Research, at the Perelman School of Medicine, University of Pennsylvania.

"With the new neuron model system of Parkinson's disease pathologies our lab has developed recently, we demonstrated that these aberrant clumps in cells resist degradation as well as impair the function of the macroautophagy system, one of the major garbage disposal systems within the cell."

Macroautophagy, literally self eating, is the degradation of unnecessary or dysfunctional cellular bits and pieces by a compartment in the cell called the lysosome.

Lee, also a professor of Pathology and Laboratory Medicine, and colleagues published their results in the early online edition of the Journal of Biological Chemistry this week.

Alpha-synuclein (?-syn ) diseases all have clumps of the protein and include Parkinson's disease (PD), and array of related disorders: PD with dementia , dementia with Lewy bodies, and multiple system atrophy. In most of these, ?-syn forms insoluble aggregates of stringy fibrils that accumulate in the cell body and extensions of neurons.

These unwanted ?-syn clumps are modified by abnormal attachments of many phosphate chemical groups as well as by the protein ubiquitin, a molecular tag for degradation. They are widely distributed in the central nervous system, where they are associated with neuron loss.

Using cell models in which intracellular ?-syn clumps accumulate after taking up synthetic ?-syn fibrils, the team showed that ?-syn inclusions cannot be degraded, even though they are located near the lysosome and the proteasome, another type of garbage disposal in the cell.

The ?-syn aggregates persist even after soluble ?-syn levels within the cell are substantially reduced, suggesting that once formed, the ?-syn inclusions are resistant to being cleared. What's more, they found that ?-syn aggregates impair the overall autophagy degradative process by delaying the maturation of autophagy machines known as autophagosomes, which may contribute to the increased cell death seen in clump-filled nerve cells. Understanding the impact of ?-syn aggregates on autophagy may help elucidate therapies for ?-syn-related neurodegeneration.

###

University of Pennsylvania School of Medicine: http://www.uphs.upenn.edu/news/

Thanks to University of Pennsylvania School of Medicine for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127519/Parkinson_s_disease_protein_gums_up_garbage_disposal_system_in_cells

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Opposites attract: How cells and cell fragments move in electric fields

Mar. 28, 2013 ? Like tiny, crawling compass needles, whole living cells and cell fragments orient and move in response to electric fields -- but in opposite directions, scientists at the University of California, Davis, have found. Their results, published April 8 in the journal Current Biology, could ultimately lead to new ways to heal wounds and deliver stem cell therapies.

When cells crawl into wounded flesh to heal it, they follow an electric field. In healthy tissue there's a flux of charged particles between layers. Damage to tissue sets up a "short circuit," changing the flux direction and creating an electrical field that leads cells into the wound. But exactly how and why does this happen? That's unclear.

"We know that cells can respond to a weak electrical field, but we don't know how they sense it," said Min Zhao, professor of dermatology and ophthalmology and a researcher at UC Davis' stem cell center, the Institute for Regenerative Cures. "If we can understand the process better, we can make wound healing and tissue regeneration more effective."

The researchers worked with cells that form fish scales, called keratocytes. These fish cells are commonly used to study cell motion, and they also readily shed cell fragments, wrapped in a cell membrane but lacking a nucleus, major organelles, DNA or much else in the way of other structures.

In a surprise discovery, whole cells and cell fragments moved in opposite directions in the same electric field, said Alex Mogilner, professor of mathematics and of neurobiology, physiology and behavior at UC Davis and co-senior author of the paper.

It's the first time that such basic cell fragments have been shown to orient and move in an electric field, Mogilner said. That allowed the researchers to discover that the cells and cell fragments are oriented by a "tug of war" between two competing processes.

Think of a cell as a blob of fluid and protein gel wrapped in a membrane. Cells crawl along surfaces by sliding and ratcheting protein fibers inside the cell past each other, advancing the leading edge of the cell while withdrawing the trailing edge.

Assistant project scientist Yaohui Sun found that when whole cells were exposed to an electric field, actin protein fibers collected and grew on the side of the cell facing the negative electrode (cathode), while a mix of contracting actin and myosin fibers formed toward the positive electrode (anode). Both actin alone, and actin with myosin, can create motors that drive the cell forward.

The polarizing effect set up a tug-of-war between the two mechanisms. In whole cells, the actin mechanism won, and the cell crawled toward the cathode. But in cell fragments, the actin/myosin motor came out on top, got the rear of the cell oriented toward the cathode, and the cell fragment crawled in the opposite direction.

The results show that there are at least two distinct pathways through which cells respond to electric fields, Mogilner said. At least one of the pathways -- leading to organized actin/myosin fibers -- can work without a cell nucleus or any of the other organelles found in cells, beyond the cell membrane and proteins that make up the cytoskeleton.

Upstream of those two pathways is some kind of sensor that detects the electric field. In a separate paper to be published in the same journal issue, Mogilner and Stanford University researchers Greg Allen and Julie Theriot narrow down the possible mechanisms. The most likely explanation, they conclude, is that the electric field causes certain electrically charged proteins in the cell membrane to concentrate at the membrane edge, triggering a response.

The team also included Hao Do, Jing Gao and Ren Zhao, all at the Institute for Regenerative Cures and the UC Davis departments of Ophthalmology and Dermatology. Sun is co-advised by Mogilner and Zhao; Gao is now working at Yunnan Normal University, Kunming, China, and Ren Zhao is at the Third Military Medical University, Chongqing, China.

The work was funded by the National Institutes of Health, the California Institute for Regenerative Medicine and the National Science Foundation.

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The above story is reprinted from materials provided by University of California - Davis.

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Journal Reference:

  1. Yaohui Sun, Hao Do, Jing Gao, Ren Zhao, Min Zhao, Alex Mogilner. Keratocyte Fragments and Cells Utilize Competing Pathways to Move in Opposite Directions in an Electric Field. Current Biology, 2013; DOI: 10.1016/j.cub.2013.02.026

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/matter_energy/biochemistry/~3/lasFFKFuUus/130328125100.htm

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America: Time to shake the salt habit?

Mar. 27, 2013 ? The love affair between U.S. residents and salt is making us sick: high sodium intake increases blood pressure, and leads to higher rates of heart attack and strokes. Nonetheless, Americans continue to ingest far higher amounts of sodium than those recommended by physicians and national guidelines.

A balanced review of the relevant literature has been published in the March 27, 2013 edition of The New England Journal of Medicine. Theodore A. Kotchen, MD, professor of medicine (endocrinology), and associate dean for clinical research at the Medical College of Wisconsin, is the lead author of the article.

Dr. Kotchen cites correlations between blood pressure and salt intake in a number of different studies; typically, the causation between lowering salt intake and decreased levels of blood pressure occur in individuals who have been diagnosed with hypertension. Although not as pronounced, there is also a link between salt intake and blood pressure in non-hypertensive individuals. Additionally, recent studies have demonstrated that a reduced salt intake is associated with decreased cardiovascular disease and decreased mortality.

In national studies in Finland and Great Britain, instituting a national salt-reduction program led to decreased sodium intake. In Finland, the resulting decrease in systolic and diastolic blood pressures corresponded to a 75 -- 80 percent decrease in death due to stroke and coronary heart disease.

Nevertheless, not all investigators concur with population-based recommendations to lower salt intake, and the reasons for this position are reviewed.

"Salt is essential for life, but it has been difficult to distinguish salt need from salt preference," said Dr. Kotchen. "Given the medical evidence, it seems that recommendations for reducing levels of salt consumption in the general population would be justifiable at this time." However, in terms of safety, the lower limit of salt consumption has not been clearly identified. In certain patient groups, less rigorous targets for salt reduction may be appropriate.

Co-authors are Allen W. Cowley, Jr., PhD, James J. Smith and Catherine Welsh Smith Professor in Physiology, and Harry and Gertrude Hack Term Professor and chairman of Physiology, the Medical College of Wisconsin; Edward D. Frohlich, MD, Alton Ocshner Distinguished Scientist at the Ochsner Clinic Foundation in New Orleans, La.

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Story Source:

The above story is reprinted from materials provided by Medical College of Wisconsin.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Theodore A. Kotchen, Allen W. Cowley, Edward D. Frohlich. Salt in Health and Disease ? A Delicate Balance. New England Journal of Medicine, 2013; 368 (13): 1229 DOI: 10.1056/NEJMra1212606

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/living_well/~3/xgaeOmcfU_o/130328091752.htm

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Airlines should charge for overweight passengers, economist ...

Airlines around the globe have gone to great lengths in recent years to reduce the weight they carry, with an eye to decreasing fuel requirements and increasing profit.

The Great Seat Squeeze: How airlines are trying to pack more people on a plane without anybody knowing

Without much fanfare, WestJet Airlines Ltd. has been quietly rolling out some strategic changes to its fleet of Boeing 737s in recent weeks, altering the cabin configuration fairly dramatically to add a new class of seating, all the while packing in more travelers in the rest of its planes.

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That was especially true when soaring fuel prices in 2008 threatened to upend the industry ? a year before the recession actually did. But one economist suggests airlines haven?t gone far enough, that it?s time airlines built a system to monetize their greatest weight variable: the passenger.

Removing excess weight from an aircraft can have a tremendous impact on overall profitability and allows it to be more competitive by keeping fares lower.?WestJet Airlines Ltd., for example, has gone to extraordinary measures to reduce weight, from shrinking the size of its in-flight magazine and printing it on lighter paper stock to using a lightweight paint on the aircraft.?Simple things like switching to lighter service carts are saving roughly 1.8 million litres in fuel a year, the carrier said.

Air Canada has done the same, switching to lighter seat covers, carpeting, and even using iPads on flight decks rather than manuals, which save about 40 kilograms per flight.

Both airlines are reducing the amount of water ? even the amount of fuel ? they carry on shorter flights to lighten the load.?The benefits are clear ? Air Canada estimates that for each kilogram it removes from one of its Boeing 763 aircraft, it will save 3,925 kilograms of fuel every year.

At the same time, while charging for excess weight for checked bags has long been the standard, charging to check a second bag ? even a first ? has become common.

Air Canada and WestJet will also be rolling out higher-density cabins in the coming months using lightweight seats that allow for more passengers without overly impacting comfort or the weight of the aircraft.

Many passengers ask why airlines only charge for overweight baggage but not for overweight passengers, if weight is the key concern for an airplane operation and more weight results in more fuel consumption

But while passengers might be already feeling the squeeze, an economist from Norway has another modest proposal for airlines to better balance the weight they carry with the revenue they collect by charging passengers based on overall weight ? including themselves and their luggage.

Bharat Bhatta specializes in econometrics and choice modeling and is an economist working as an associate professor in Sogn og Fjordane University College in Norway. He argues that more airlines should consider a ?pay-as-you-weigh? model for ticketing where those who weighed more than the average passenger would pay more, while those who weighed less would get a discount.

In the March issue of the Journal of Revenue and Pricing Management, Mr. Bhatta wrote that the model would not be discriminatory toward obese people and would also strike a better balance for those who are underweight.

?A passenger gets a fixed amount of weight for the baggage and an unlimited amount of weight for oneself under the status quo,? he wrote in the article.

?Many passengers ask why airlines only charge for overweight baggage but not for overweight passengers, if weight is the key concern for an airplane operation and more weight results in more fuel consumption,? he added.

To be clear, no airline has openly discussed implementing such measures since Irish low-cost carrier Ryan Air first floated the idea in 2009 after nearly a third of its passengers responding to an online survey said they supported the move.

Richard Bartrem, WestJet spokesman, said he believes no carrier, even the ultra-low-cost carriers, has taken the step yet because of the backlash they would receive from consumers.

?The public uproar would not be worth the risk, ? he said. ?Who would want to be the one to take the first step??

But the Canadian Transportation Agency has no specific precedents that would prevent such measure from being implemented, said Chantal Laflamme, a spokesperson for the agency.

The Supreme Court did uphold the CTA?s one-passenger-one-fare policy in 2008, which now prevents Air Canada, WestJet and Jazz from charging the disabled for a second seat, including those who are considered disabled by obesity and unable to fit in a single seat. But the regulations in Canada do not apply to people who are obese but not disabled as a result of their obesity.

Both WestJet and Air Canada require a medical certificate for obese passengers to qualify for the extra seat at no charge. In order to remove error or confusion, Air Canada?s assessment form instructs the qualifying physician to seat the patient on a ?paper covered examination table? and carefully measure and record the size of their posterior. In many other countries, the free seat is not an option.

Several international carriers, including Southwest Airlines, encourage obese passengers to purchase an extra seat under their so-called ?customer of size policy,? which will see the last person to check in to a full flight bumped if it is deemed that the person is too large to fit into a single seat. But not necessarily the obese one.

Last year, the U.K. Court of Appeal also opened the door to so-called ?fat taxes? on passengers when it ruled that the Montreal Convention, a framework of international rules and regulations on air travel, takes precedence over parts of Britain?s discrimination and disability laws once the aircraft leaves the runway, eliminating a passenger?s ability to seek redress for being charged for a second seat.

Linda McKay-Panos, a lawyer and executive director of the Alberta Civil Liberties Research Centre, was the complainant in one of the cases that led to the Supreme Court?s one-passenger-one-fare policy after she was forced to fly in an economy seat on an Air Canada flight in 1997 that couldn?t accommodate her.

Her 11-year fight with the airline to change its policy to accommodate obese people contributed to the changes it has since adopted to not charge for a second seat.

She said the pay-as-you-weigh policy might make a good economic argument, but doesn?t think it would fly here in Canada.

?I think that?s ridiculous,? she said. ?That?s a slippery slope of blaming people. When you?re in the business of serving the public, you take them as they come.?

While the statement may prove contentious, Mr. Bhatta argues the current system is already discriminatory in that passengers who weigh less or are carrying less luggage are already subsidizing the flights of those who are carrying more weight and raise the overall average weight of passengers and therefore fares.

Mr. Bhatta argues airlines have dynamic pricing models that charge different prices to different passengers based on when they book their flights, whether they?re flying direct or with a layover, among other variables to maximize the price of fares and minimize the amount of empty seats on their flights.

?We emphasize that the fare policy that charges heavier passengers more but does not give any discount to lighter passengers can benefit only the airlines but harm the passengers and the society at large,? he said.

But he said carriers are failing to maximize their profitability by not charging more to passengers who are above the average weight and cost them more to fly, he said.

?Charging according to weight is a standard principle in transporting goods by any transport modes such as rail, road, human or pack animals, air and water,? he said.

The more weight in a plane, the more fuel it costs to fly; as a result it is justifiable to say that a passenger should contribute to the cost of flying the plane

?The more weight in a plane, the more fuel it costs to fly; as a result it is justifiable to say that a passenger should contribute to the cost of flying the plane?? he added.

But Mr. Bhatta acknowledged it may be a difficult system to enforce without impacting check-in times and causing major disruptions for the travelling public.

He floated several models from charging based strictly on the weight of the passenger plus their luggage, or the passenger themselves with a weight limit on their bags.

Or, he said, airlines could determine an average weight for a passenger and their bags, and grant them a 25% window on other side before the fees or discounts kick in.

He argued the measures could be enforced either through self-declaration at the time of purchase, with random checks to enforce the issue, or charging a fixed fare with an extra fee tacked on or refunded to a credit card after a weigh-in.

But he also argued it could cut down on security lines, because it could replace the need to charge for a first and second checked bag and reduce carry-on luggage.

?Although every passenger will not benefit from the model, one does not pay for others? excess weight as in an average fare policy. Charging according to weight and space is a universally accepted principle not only in transportation but also in other services,? he said.

What do you think? Should airlines start charging passengers by the pound? Take our poll.

Source: http://business.financialpost.com/2013/03/29/should-airlines-start-charging-passengers-by-the-pound/

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